{"id":241,"date":"2020-07-01T11:49:53","date_gmt":"2020-07-01T09:49:53","guid":{"rendered":"http:\/\/pharmacie-kerangal.com\/preparatoire\/?p=241"},"modified":"2021-03-26T17:51:25","modified_gmt":"2021-03-26T16:51:25","slug":"preparation-magistrale-sirolimus-rapamycine-creme-sclerose-tubereuse-de-bourneville","status":"publish","type":"post","link":"https:\/\/pharmacie-kerangal.com\/preparatoire\/article\/preparation-magistrale-sirolimus-rapamycine-creme-sclerose-tubereuse-de-bourneville\/","title":{"rendered":"Pr\u00e9paration magistrale: Sirolimus (Rapamycine) 0.1% cr\u00e8me dans la scl\u00e9rose tub\u00e9reuse de Bourneville"},"content":{"rendered":"\n<p>La scl\u00e9rose tub\u00e9reuse de Bourneville est une maladie g\u00e9n\u00e9tique. Elle se caract\u00e9rise par la formation de tumeurs b\u00e9nignes d\u00e9figurantes. Ces tumeurs peuvent \u00eatre trait\u00e9es gr\u00e2ce \u00e0 l&rsquo;application d&rsquo;une pr\u00e9paration magistrale de Sirolimus (rapamycine) 0.1% en cr\u00e8me<\/p>\n\n\n\n<p>La scl\u00e9rose tub\u00e9reuse de Bourneville est une maladie g\u00e9n\u00e9tique syst\u00e9mique. C&rsquo;est une maladie rare qui touche environ une personne sur 20 000 et se caract\u00e9rise par la formation de tumeurs b\u00e9nignes d\u00e9figurantes. Les traitements pour pallier ces troubles font souvent appel \u00e0 la chirurgie et au traitement par laser. Ce sont des interventions Douloureuses, difficiles \u00e0 pratiquer et d&rsquo;une relative efficacit\u00e9.<\/p>\n\n\n\n<p>Or, depuis une dizaine d\u2019ann\u00e9es, de nouveaux traitements m\u00e9dicamenteux utilisant des inhibiteurs de mTOR en application topique, et notamment le Sirolimus, ont \u00e9t\u00e9 publi\u00e9s. Ces derniers ont montr\u00e9 leur efficacit\u00e9 et leur s\u00e9curit\u00e9. Cependant, aucune forme topique n\u2019est pour le moment commercialis\u00e9e en FRANCE ;<\/p>\n\n\n\n<p>Le CHU d&rsquo;Angers \u00e0 travaill\u00e9 sur une formulation, r\u00e9alisable sous forme de pr\u00e9paration magistrale et a fait l\u2019objet d&rsquo;une th\u00e8se pour le dipl\u00f4me d&rsquo;\u00e9tat de docteur en pharmacie en 2016<\/p>\n\n\n\n<p>Cette pr\u00e9paration peut \u00eatre prise en charge par l\u2019assurance maladie car elle respecte les conditions d\u00e9finies par le code de la s\u00e9curit\u00e9 sociale, \u00e0 savoir :<br>&#8211; L&rsquo;objectif th\u00e9rapeutique.<br>&#8211; L&rsquo;efficacit\u00e9 th\u00e9rapeutique, appuy\u00e9e notamment par la litt\u00e9rature<br>&#8211; L&rsquo;absence de sp\u00e9cialit\u00e9s \u00e9quivalentes disponibles<\/p>\n\n\n\n<p>la formulation qui a \u00e9t\u00e9 retenue est la suivante:<\/p>\n\n\n\n<ul><li>Sirolimus 0.03g<\/li><li>Transcutol\u00ae 1.5g<\/li><li>Excipial Hydrocr\u00e8me Qsp 30g<\/li><\/ul>\n\n\n\n<p>Conditionn\u00e9e en tube aluminium<\/p>\n\n\n\n<p>Conservation 3mois \u00e0 25\u00b0C<\/p>\n","protected":false},"excerpt":{"rendered":"<p>La scl\u00e9rose tub\u00e9reuse de Bourneville est une maladie g\u00e9n\u00e9tique. Elle se caract\u00e9rise par la formation de tumeurs b\u00e9nignes d\u00e9figurantes. Ces tumeurs peuvent \u00eatre trait\u00e9es gr\u00e2ce \u00e0 l&rsquo;application d&rsquo;une pr\u00e9paration magistrale de Sirolimus (rapamycine) 0.1% en cr\u00e8me La scl\u00e9rose tub\u00e9reuse de Bourneville est une maladie g\u00e9n\u00e9tique syst\u00e9mique. C&rsquo;est une maladie rare qui touche environ une personne &hellip; <a href=\"https:\/\/pharmacie-kerangal.com\/preparatoire\/article\/preparation-magistrale-sirolimus-rapamycine-creme-sclerose-tubereuse-de-bourneville\/\">Continued<\/a><\/p>\n","protected":false},"author":1,"featured_media":309,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[1],"tags":[23,16,18,17,19,21,20,22],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v17.3 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Pr\u00e9paration magistrale: Sirolimus (Rapamycine) 0.1% cr\u00e8me dans la scl\u00e9rose tub\u00e9reuse de Bourneville - pr\u00e9paratoire Kerangal<\/title>\n<meta name=\"description\" content=\"Cr\u00e8me \u00e0 0.1% de Rapamycine r\u00e9alisable en pharmacie sous forme de pr\u00e9paration magistrale. 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